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時間:2022-08-16 來源:本站 點擊:258次
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Pfizer says COVID******

Pfizer said on Friday that a clinical trial of its pill to treat COVID-19 had shown it is highly effective, hailing it as a big step toward ending the pandemic.。

A simple pill to treat the coronavirus at home has been sought since the start of the global health crisis. So far all treatments have been either intravenous or vaccine shots.。

Pfizer's is the second anti-COVID pill after that of Merck, which is actually an influenza medicine rebranded to fight the coronavirus. Pfizer's has been created specifically to fight COVID-19.。

The Pfizer drug called Paxlovid achieved an 89 percent reduction in risk of hospitalization or death among adult patients with COVID-19 who are at high risk of progressing to severe illness, the US company said.。

The results from the middle-to-late stage clinical trial were so strong that Pfizer will stop recruiting new people for the trial, it said.。

Pfizer will submit the data to the Food and Drug Administration as soon as possible as part of its "rolling submission" for Emergency Use Authorization.。

"Today's news is a real game-changer in the global efforts to halt the devastation of this pandemic," said Pfizer CEO Albert Bourla.。

"These data suggest that our oral antiviral candidate, if approved or authorized by regulatory authorities, has the potential to save patients' lives, reduce the severity of COVID-19 infections, and eliminate up to nine out of 10 hospitalizations," he added.。

Bourla told CNN he hopes the company can submit its authorization request before the Thanksgiving holiday, which this year falls on November 25.。

President Joe Biden said in remarks at the White House that the government has already secured millions of doses of the new medication.。

He said the pill "would be another tool in our toolbox to protect people from the worst outcomes of COVID-19."

The main analysis of the Pfizer pill data looked at numbers from 1,219 adults in North and South America, Europe, Africa and Asia.。

In the days immediately after symptoms appeared, some of them were given the experimental drug and others got a placebo – for five days, every 12 hours.。

Ten people who took the placebo died, while among those who got the Pfizer medication, none did.。

The search for a pill。

Several companies are working on so-called oral antivirals, which would mimic what the drug Tamiflu does for influenza and prevent the disease from progressing to severe.。

Britain on Thursday became the first country to approve an anti-COVID pill, as it greenlit the use of Merck's antiviral drug called molnupiravir to treat patients suffering from mild to moderate coronavirus.。

Pfizer's product is known as a "protease inhibitor" and has been shown in lab testing to jam up the virus' replication machinery.。

If it works in real life, it will likely only be effective at the early stages of infection.。

By the time COVID-19 progresses to severe disease, the virus has largely stopped replicating and patients suffer from an overactive immune response.。

Until now, COVID-19 therapeutics such as monoclonal antibodies and Gilead's remdesivir – authorized for use in the EU under the name Veklury – have been administered intravenously.。

Merck's molnupiravir was initially developed as an inhibitor of influenza and respiratory syncytial virus – two other important acute respiratory infections – by a team at Emory University in Atlanta, Georgia.。

Britain, which has been one of the countries hardest hit by the pandemic, announced on October 20 that it had ordered 480,000 doses of molnupiravir.。

Pfizer is carrying out two other clinical trials with its pill: among people who are not at risk of progressing to severe COVID-19, and among people close to someone with COVID-19 to see if it protects them against the illness.。

Besides Pfizer and Merck, the Swiss pharma giant Roche is also working on a COVID pill.。

At least 31 drown as migrant boat sinks in English Channel******

AFP。

Migrants are helped ashore from a Royal National Lifeboat Institution lifeboat at Dungeness in southeast England on Wednesday. Dozens of others died in a separate sinking.。

At least 31 migrants bound for Britain died on Wednesday when their boat sank in the English Channel, in what France's interior minister called the biggest migration tragedy on the dangerous crossing to date.。

Interior Minister Gerald Darmanin said 34 people were believed to have been on the boat. Authorities found 31 bodies – including those of five women and a young girl – and two survivors, he said. One person appeared to still be missing. The nationalities of the travelers was not immediately known.。

The regional maritime authority, which oversees rescue operations, later said 27 bodies were found, two people survived and four others were missing and presumed drowned. The discrepancy in the numbers was not immediately explained.。

Ever-increasing numbers of people fleeing conflict or poverty in Afghanistan, Sudan, Iraq, Eritrea or elsewhere are risking the perilous journey in small, unseaworthy craft from France, hoping to win asylum or find better opportunities in Britain. The crossings have tripled this year from 2020, and another 106 migrants were rescued in French waters on Wednesday alone.。

A joint French-British search operation for survivors of the sinking was called off late on Wednesday. Both countries cooperate to stem migration across the Channel but also accuse each other of not doing enough – and the issue is often used by politicians on both sides pushing an anti-migration agenda.。

Four suspected traffickers were arrested on Wednesday on suspicion of being linked to the sunken boat, Darmanin told reporters in the French port city of Calais. He said two of the suspects later appeared in court.。

The regional prosecutor opened an investigation into aggravated manslaughter, organized illegal migration and other charges after the sinking.。

Lille Prosecutor Carole Etienne said officials were still working to identify the victims and determine their ages and nationalities, and that the investigation may involve multiple countries.。

"It's a day of great mourning for France, for Europe, for humanity to see these people die at sea," Darmanin said. He lashed out at "criminal traffickers" driving thousands to risk the crossing. Activists demonstrated outside the port of Calais on Wednesday night, accusing governments of not doing enough to respond to migrants' needs. Hundreds of people live in precarious conditions along the French coast, despite regular police patrols and evacuation operations.。

The bodies were brought to the Calais port, said Jean-Marc Puissesseau, head of the ports of Calais and Boulogne. "We were waiting for something like this to happen," he said, given the growing numbers of people risking the passage. Aid groups blamed European governments for increasingly hard-line migration policies.。

"The UK is not a choice, it is an escape, an escape for people fleeing the lack of welcome in Europe," said Nikolai Posner of French charity Utopia 56.。

Darmanin urged coordination with the UK, saying "the response must also come from Great Britain."

British Prime Minister Boris Johnson and French President Emmanuel Macron spoke after the sinking and agreed "that it is vital to keep all options on the table to stop these lethal crossings and break the business model of the criminal gangs behind them," Johnson's office said. Macron stressed "the shared responsibility" of France and the UK.。

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国家卫健委:昨日新增本土确诊病例87例 在其中西安75例******

  12月24日0—24时,31个省(自治州、市辖区)和兵团汇报增加确诊病例140例。在其中海外键入病例53例(上海市15例,天津市9例,陕西省8例,广东省6例,广西省5例,湖南省4例,云南省2例,浙江省1例,福建省1例,河南1例,四川1例),含9例由没有症状的病毒感染者变为确诊病例(湖南省4例,陕西省4例,四川1例);当地病例87例(陕西省78例,在其中西安75例、延安市2例、宝鸡市1例;广西省5例,均在广西防城港市;云南省4例,均在昆明)。无增加身亡病例。增加疑是病例6例,均为海外键入病例(上海市4例,浙江省2例)。

  当天增加痊愈康复病例110例,消除医学观察的密切接触者5113人,危重症病例与前一日一样。

  海外键入目前确诊病例696例(在其中危重症病例3例),目前疑是病例10例。累计确诊病例10846例,累计痊愈康复病例10150例,无身亡病例。

  截止到12月24日24时,据31个省(自治州、市辖区)和兵团汇报,目前确诊病例1881例(在其中危重症病例9例),累计痊愈康复病例94354例,累计身亡病例4636例,累计汇报确诊病例100871例,目前疑是病例10例。累计跟踪到密切接触者1403530人,尚在医学观察的密切接触者53923人。

  31个省(自治州、市辖区)和兵团汇报增加没有症状的病毒感染者24例,在其中海外键入20例,当地4例(均在广西钦州市);当天变为确诊病例9例(均为海外键入);当天消除医学观察20例(均为海外键入);尚在医学观察的没有症状的病毒感染者492例(海外键入452例)。

  累计接到港澳地区通告确诊病例29505例。在其中,香港特别行政区12555例(康复12189例,身亡213例),澳门特区77例(康复77例),台湾省16873例(康复13742例,身亡850例)。



来源于:国家卫健委网址。

编写:田媛。

巾帼不让须眉!路边私家车突然着火 西咸公交女司机帮忙灭火******

车上乘客纷纷对王丽丽果断勇敢的行为点赞:“这样的公交司机,来一打。”此时正值早高峰,车流量大,如果火情得不到及时处置,很有可能造成严重的后果。据着火车主回忆:“当时车辆起火很快,驾驶员救火很熟练,很专业,如果不及时扑救,后果不堪设想。”

在王丽丽眼里,路遇小车着火,作为公交车长帮忙灭火是应该的。她说,公交车长不仅是城市的摆渡者,更是城市的守护者。

华商报记者 赵瑞利

逃离大厂后,我10个月还债34万

1.江西一工地挖出一枚航空炸弹,民警妥善处置

2.暑期景区夜游人次增长165% 海昌携程共推夜经济2.0产品生态体系

3.政府工作报告中,这些内容与国防和军队建设息息相关

4.高温红色预警!11省区市部分地区最高温超40℃

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